I sense that your questions are asked in good faith. I hope nobody takes exception to them, as they tend to do on the internet.
I am 5'6", 133 lbs., in my mid-50's, female, and I'm the primary driver of our T1N 2500 (my husband is basically my relief driver... it's an agreed spousal division of labor thing, details omitted for brevity). Our Class B as built-out and loaded with gear is just a few hundred pounds short of the GVWR of 8,550; I imagine that most other upfit T1Ns would be similar, regardless of Class B brand.
The driving challenges with the T1N are genderless IMO. My husband and I were both equally miserable until we replaced the sway bar and upgraded the rear shocks to the Koni variable kind (I forget the name). Those two simple mods made all the difference. We are planning on air suspension in the future (have the equipment on order), but that's for comfort sake, not because the driving is difficult.
The seats on the T1Ns generally get better than average reviews - very adjustable and no problems whatsoever for a woman of my size there. I actually prefer those seats to almost any other vehicle I've ever driven.
Some people do pick a bone with the steering wheel angle, which cannot be altered, but I've not been aware of any male vs. female difference of opinion there.
Overall, I think more important than gender is the age and physical fitness of the driver. I am more fit than most women my age, but of course I can't hold a candle to the strength of my husband who is 8 inches taller and 50 pounds heavier than I am. But if someone has health issues that prevent full mobility, that might be something to think about in the T1N context.
In a few weeks, I'll be driving solo, three thousand miles. The roads through the northeastern US scare the crap out of me, but that's because of the northeast itself - it has nothing to do with the T1N's driveability.
