I don't think I could go to the larger size tire in the size you're running or I would just to be able to stay with Defender LTX M/S.
I generally like the same or slightly larger tires, but when I had my 2-1/2 inch lift installed, the front tires scrubbed on the Airstream installed mud flaps. I trimmed off the part of the mud flap that extended into the wheel well and it solved the problem.
I was surprised the lift make the front scrub where they didn't previously, but the front tires do come awfully close the rear of the wheel well on tight turns. For that reason, I'm afraid of going up-sized on new tires.
I take it this was not a problem on your Roadtrek 190?
The larger tires are close but don't hit anywhere on the Roadtrek and we have on front wheel that sits a bit to rear and it still clears.
From you pic it looks like your van has aluminum wheels on it, and if so they would almost certainly be the wrong offset for the Chevy vans which are +28mm. Most aluminums are either zero or -6 from that era. The offset outboard like the aluminum wheels gives, make the wheel and tire move more for and aft as the wheels turn, increasing the possibility of hitting. If you have a steel wheel as a spare, it would probably be the right offset so you could put it on and see if you get more clearance. The bigger tires will be .5" bigger on the radius so come .5" closer on the OD to the ground effect stuff and wheelwell rear.
Wife and I sat down and talked about the whole tire thing. For reference she is more risk aversive than I am so very aversive, especially on tires for some reason. All the talk about why are the Agilis changing over time and miles has her scared to some degree and me very hesitant.
The digging I have done showed up that I can get some 2008ish GMC Sierra 3500 aluminum wheels in the correct 28mm offset and 17" diameter. They are 7.5" wide so perfect the a 265-70-16. By luck we can get that tire size in a Michelin LTX MS2 tire which is an XL load capacity with the same 3415# load capacity as our current tires, the same 31.6" diameter, same cross section, slightly wider tread. Bonus is S speed rating that actually is what Chevy specs stock. All of this should make our current spare work fine with the new setup.
Worrying about tires when on a trip would really suck, we both agreed and decided to just do it and see how it goes.
The extra cost to just going to MS tires in our size is not all that bad, depending on what you define as bad. The used, OEM, "reconditioned" (junkyard spiffed up a little most times) wheels are just under $800 to the door. The new tires are about $50 more than the 16" MS tires would be. Will need new metal bolt in valve stems for probably $30 extra. About $900 total to get MS2 instead of MS and with the S rating instead or R of the MS. 70 series tires should handle a bit better but time will tell on that.
Will it all be worth it, we will see how it works out. If the tires handle well, it probably will be as the 16" seem to be getting phased out as Michelin has already gotten rid of the 245/75/16 in some tire lines with 265 probably also on the chopping block in the future. 17" tires should be available longer, I hope.
If we were just doing a tire size increase, going to 17" and 70 series MS2 tires would be no brainer, I think, as the costs would be very close to a wash with the correct offset steel wheels getting as expensive as they are now. If we like the new tires, at least we can probably get $400-600 for our old wheels with Agilis on them.