Both 6V and 12V lead acid batteries suffer from self discharge.
Paralleled batteries will seek a state of equilibrium basically meaning that the stronger battery will end up at the resting voltage of the weaker battery. That's pretty much why the strong recommendation is to parallel batteries of the same age, brand, type, capacity, match wire size and length and match terminations. You the minimize the impact of the negative effects that way.
There's always going to be an imbalance of the individual cells in both 6V and 12V batteries.
6 volt batteries in series themselves can end up surprisingly out of balance.
Some time ago, E-trek owner photolimo posted the voltage readings of his two groups of series connected 6 volt batteries on solar float charge.
Quote:
Group 1
6.33v + 6.43v + 6.94v + 6.88v = 26.58V
Group 2
6.43v + 6.34v + 6.94v + 6.88v = 26.59v
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You'd have to think that the over-voltage batteries will have a much shorter life.