Yes, we certainly have heard this, mostly from ARV who was originally, at least, reporting second-hand information from "ambulance companies and others".
(My memory was that they eventually tried one themselves, but I can find no current evidence for that, so I may have been wrong.) Their purported issue was "dust clogging". I have never found this to be plausible, since nearly all automotive A/C evaporators are horribly exposed to road dust, and they work fine.
In any event, back when these rumors got started, most or all such systems (including the infamous RoadTrek models) had vertically-mounted evaporators, usually perpendicular to the direction of travel, which is pretty obvious pessimal. This is because the then-available evaporators were designed for the back of truck cabs and did not work properly when mounted horizontally. But, the Pro-air unit I am using works fine horizontally-mounted. I expect this to make a big difference, for aerodynamic reasons. If I am wrong, I will devise a protection-scheme (e.g., electric louvers that close while underway. I am betting it will be just fine, though.
Finally, even if it turns out to require routine maintenance (which I doubt), I would STILL go this route. There are so many advantages, aesthetically, practically, and acoustically, that it would be worth the hassle to me. We'll see...